The Powell-McMullan House enjoys a picturesque setting in Greene County is framed by the Blue Ridge Mountains and the South River that flows across the property frontage. The house is a simple, but ample, frame dwelling built about 1800 that was more than doubled in size in 1842. Architectural evidence suggests that the original house was a two–story, hall-and–parlor-plan dwelling constructed during the ownership of Ruth Powell Breeden, daughter of an early settler. This section features floor-to-ceiling beaded sheathing with hand-wrought rosehead nails, pit-sawn timbers, and mortise-and-tenon joinery. The Greek Revival addition was made by Jeremiah McMullan, son of another early settler and a Methodist circuit–riding preacher. While typically plain, the Powell-McMullan House is a good example of the vernacular architecture of the area.